Author

P. B. Dirks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Research Focus:cell type annotation· 5 Research Focus:differential expression· 5 Research Focus:gene regulatory network inference· 5 Assay:bulk RNA-seq· 4 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

M. D. Taylor· 3 shared A. J. Mungall· 2 shared A. Nikolic· 2 shared F. J. Coutinho· 2 shared F. M. Cavalli· 2 shared J. Reimand· 2 shared K. Ellestad· 2 shared M. A. Marra· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

M. D. Taylor

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Author profile →

7 papers

Recent·Most cited

Pan-cancer analysis of the ion permeome reveals functional regulators of glioblastoma aggression

A. T. Bahcheli, H.-K. Min, M. Bayati, W. Dong, A. Fortuna, H. Zhao, I. Dzneladze, J. Chan, X. Chen, K. Guevara-Hoyer, P. B. Dirks, X. Huang, J. Reimand

The paper identifies survival-associated ion permeome genes across 29 cancer types and shows their role in glioblastoma aggression through functional experiments.

bioRxiv · Apr 7, 2023Cancer Biology

In vivo functional genomics identifies essentiality of potassium homeostasis in medulloblastoma

J. J. Fan, X. Wang, A. W. Erickson, P. Skowron, X. Wang, X. Chen, G. Shan, S. Bahrampour, Y. Xiong, W. Dong, N. Abeysundara, M. A. Francisco, R. J. Pusong, R. A. Suarez, H. Farooq, , X. Huang

The paper identifies potassium homeostasis as essential for medulloblastoma maintenance using a novel transposon system in mice and human samples.

bioRxiv · Jul 23, 2022Cancer Biology

The Mediator tail module cooperates with proneural factors to determine fate identity in Glioblastoma.

M. Ahmadi, G. MacLeod, N. Rajakulendran, M. Kosic, A. Yang, F. Molaei, S. Lin, Z. Steinhart, N. I. Park, P. B. Dirks, S. Angers

The paper identifies MED24 and MED25 as essential for ASCL1-mediated neuronal differentiation in GSCs and other cell types, revealing a role for the Mediator tail module in this process.

bioRxiv · May 4, 2021 · PreprintCell Biology

The white matter is a pro-differentiative microenvironment for glioblastoma

L. J. Brooks, M. P. Clements, J. J. Burden, D. Kocher, L. Richards, S. Castro Devesa, M. Woodberry, M. Ellis, L. Zakka, Z. Jaunmuktane, S. Brandner, G. Morrison, S. M. Pollard, P. B. Dirks, S. Marguerat, S. Parrinello

This study identifies the white matter as a differentiative niche for glioblastomas, showing that tumour cells in contact with it acquire pre-oligodendrocyte-like fate, leading to reduced proliferation and invasion.

bioRxiv · Nov 14, 2020 · PreprintCancer Biology

Comprehensive analysis of lncRNAs reveals candidate prognostic biomarkers in multiple cancer types

K. Isaev, L. Jiang, C. A. Lee, R. Tsai, F. Coutinho, P. B. Dirks, D. Schramek, J. Reimand

The paper identifies 179 prognostic lncRNAs across 29 cancer types using machine learning, showing their association with patient risk and tumor subtypes.

bioRxiv · Dec 2, 2019Cancer Biology

High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma

M. J. Johnston, A. Nikolic, N. Ninkovic, P. Guilhamon, F. M. Cavalli, S. Seaman, F. J. Zemp, J. Lee, A. Abdelkareem, K. Ellestad, A. Murison, M. M. Kushida, F. J. Coutinho, Y. Ma, A. J. Mungall, , M. Gallo

This study uses high-resolution 3D genome maps to identify CD276 as a therapeutic target in glioblastoma stem cells, showing it can suppress self-renewal.

bioRxiv · Oct 13, 2018Cancer Biology

Subclonal architecture, evolutionary trajectories and patterns of inheritance of germline variants in pediatric glioblastoma

M. Hoffman, A. H. Gillmor, D. J. Kunz, M. J. Johnston, A. Nikolic, K. Karta, J. King, K. Ellestad, N. H. Dang, F. M. Cavalli, M. M. Kushida, F. J. Coutinho, B. Luu, Y. Ma, A. J. Mungall, , M. Gallo

This study examines genetic heterogeneity and evolutionary patterns in pediatric glioblastoma using whole-genome sequencing of germline-tumor pairs, revealing subclonal architecture and complex inheritance mechanisms.

bioRxiv · Oct 12, 2018Cancer Biology