S. Brandner

Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas

This study investigates the relationship between CDKN2A mRNA expression and clinical outcomes in meningiomas, finding that high expression is associated with poorer progression-free survival and more aggressive tumor characteristics.

Farnesoid X Receptor suppresses lipid peroxidation and ferroptosis

This study identifies FXR agonists that suppress ferroptosis by upregulating protective proteins, highlighting FXR's role in preventing lipid peroxidation and ferroptotic cell death.

Harmonized single-cell landscape, intercellular crosstalk and tumor architecture of glioblastoma

This paper harmonizes 26 single-cell RNA sequencing datasets from 240 glioblastoma patients to create GBmap, revealing tumor architecture, intercellular crosstalk, and pro-angiogenic signaling sources.

Global hypo-methylation in a subgroup of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

The paper identifies a glioblastoma subgroup with global hypo-methylation and astrocytic features linked to invasion and immune changes.

Mapping prion pathology in mice using quantitative imaging: an MRI study

The paper uses MRI techniques to detect early prion disease changes in mice, identifying significant alterations in brain regions before clinical symptoms appear.

Can Chemical Exchange Saturation Transfer (CEST MRI) be used as biomarker of disease progression in Prion Disease?

This study shows that CEST MRI can detect early pathological changes in prion disease before structural or clinical signs, with significant correlations between CEST metrics and histopathological findings.

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial ependymoma

The paper identifies a novel subset of supratentorial ependymomas in children characterized by recurrent PLAGL1 fusions and distinct molecular features.

Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses

This study identifies acriflavine as a potent inhibitor of SARS-CoV-2 and other betacoronaviruses, effective in cellular models, in vivo, and ex vivo.

The white matter is a pro-differentiative microenvironment for glioblastoma

This study identifies the white matter as a differentiative niche for glioblastomas, showing that tumour cells in contact with it acquire pre-oligodendrocyte-like fate, leading to reduced proliferation and invasion.