Author

S. Parrinello

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Garcia-Diaz· 2 shared M. P. Clements· 2 shared S. Marguerat· 2 shared A. Bailey· 1 shared A. Martinez-Segura· 1 shared A. P. Gould· 1 shared A. Pöysti· 1 shared D. Kocher· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCancer Biology

C. Garcia-Diaz

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3 papers

Recent·Most cited

Diet suppresses tumour initiation by maintaining quiescence of mutation-bearing neural stem cells

V. Amodeo, T. Davies, A. Martinez-Segura, M. Clements, H. Simpson Ragdale, A. Bailey, M. Silva dos Santos, J. I. MacRae, J. Mokochinski, H. Kramer, C. Garcia-Diaz, A. P. Gould, S. Marguerat, S. Parrinello

This study shows that diet can suppress glioblastoma by restoring quiescence in p53-deficient neural stem cells through omega-3 fatty acids.

bioRxiv · Mar 9, 2022 · PreprintCancer Biology

Glioblastoma cell fate is differentially regulated by the microenvironments of the tumour bulk and infiltrative margin

C. Garcia-Diaz, E. Mereu, M. P. Clements, A. Pöysti, F. Galvez-Cancino, S. P. Castillo, L. Courtot, S. Ruiz, F. Roncaroli, Y. Yuan, S. A. Quezada, H. Heyn, S. Parrinello

This study compares glioblastoma cell fate in tumour bulk and margin, finding distinct neurogenic patterns and immune environments, with margin cells showing developmental-like trajectories and iNPCs linked to interferon signalling.

bioRxiv · Jun 11, 2021 · PreprintCancer Biology

The white matter is a pro-differentiative microenvironment for glioblastoma

L. J. Brooks, M. P. Clements, J. J. Burden, D. Kocher, L. Richards, S. Castro Devesa, M. Woodberry, M. Ellis, L. Zakka, Z. Jaunmuktane, S. Brandner, G. Morrison, S. M. Pollard, P. B. Dirks, S. Marguerat, S. Parrinello

This study identifies the white matter as a differentiative niche for glioblastomas, showing that tumour cells in contact with it acquire pre-oligodendrocyte-like fate, leading to reduced proliferation and invasion.

bioRxiv · Nov 14, 2020 · PreprintCancer Biology