Author

M. P. Czech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. Kelly· 5 shared F. Henriques· 4 shared A. Guilherme· 3 shared J. K. Kim· 3 shared A. H. Bedard· 2 shared B. Yenilmez· 2 shared E. Tsagkaraki· 2 shared R. H. Friedline· 2 shared

Activity by Year

2018-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersBioengineering

M. Kelly

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CRISPR-enhanced human adipocyte 'browning' as cell therapy for metabolic disease

E. Tsagkaraki, S. Nicoloro, T. De Souza, J. Solivan-Rivera, A. Desai, Y. Shen, M. Kelly, A. Guilherme, F. Henriques, R. Ibraheim, N. Amrani, K. Luk, S. Maitland, R. H. Friedline, L. Tauer, , M. P. Czech

This paper uses CRISPR to enhance browning of human adipocytes, improving metabolic health in mice without immunogenic Cas9 exposure.

bioRxiv · Oct 13, 2020Bioengineering

Single Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis

F. Henriques, A. H. Bedard, A. Guilherme, M. Kelly, J. Chi, P. Zhang, L. M. Lifshitz, K. Bellve, L. Rowland, B. Yenilmez, S. Kumar, Y. Wang, J. Luban, L. S. Weinstein, J. D. Lin, , M. P. Czech

This study shows that adipocyte signals can drive iWAT browning through macrophage-like cells, independent of sympathetic nerves.

bioRxiv · May 4, 2020Physiology

Resistance to Diet Induced Obesity in the Apolipoprotein E Deficient Mouse is Associated with an Attenuated Transcriptional Response in Visceral Fat

T. P. Fitzgibbons, M. Kelly, J. K. Kim, M. P. Czech

This study shows that apoE-deficient mice have a reduced transcriptional response in visceral fat to high-fat diet, linked to increased metabolic efficiency and resistance to obesity.

bioRxiv · Dec 11, 2018 · PreprintPhysiology

CRISPR delivery particles for developing therapeutic strategies in metabolic disease

Y. Shen, J. L. Cohen, S. M. Nicoloro, M. Kelly, B. Yenilmez, F. Henriques, E. Tsagkaraki, Y. J. K. Edwards, X. Hu, R. H. Friedline, J. K. Kim, M. P. Czech

This study develops CRISPR delivery particles (CriPs) for efficient gene editing in cultured cells and in vivo, demonstrating their potential for therapeutic applications in metabolic disease.

bioRxiv · Jun 21, 2018Bioengineering

Neuronal Modulation of Brown Adipose Activity Through Perturbation of White Adipocyte Lipogenesis

A. Guilherme, D. J. Pedersen, F. Henriques, A. H. Bedard, E. Henchey, M. Kelly, K. Rahmouni, D. A. Morgan, M. P. Czech

This study shows that white adipocyte lipogenesis influences brown adipose thermogenesis through neuronal signaling.

bioRxiv · May 16, 2018Cell Biology