Author

R. Puertollano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Organism:mouse· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

S. C. Watkins· 2 shared A. Pause· 1 shared A. Sodhi· 1 shared C. H. Choy· 1 shared C. T. Wallace· 1 shared C. Wallace· 1 shared C. Yu-Wei· 1 shared D. Bose· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

S. C. Watkins

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Author profile →

3 papers

Recent·Most cited

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in atrophic AMD

S. Ghosh, R. Sharma, S. Bammidi, V. Koontz, M. Nemani, M. Yazdankhah, K. M. Kedziora, C. T. Wallace, C. Yu-Wei, J. Franks, D. Bose, D. Rajasundaram, S. Hose, J.-A. Sahel, R. Puertollano, , D. Sinha

This study identifies the AKT2/SIRT5/TFEB pathway as a therapeutic target for atrophic AMD by showing its role in lysosomal dysfunction and drusen formation in RPE cells.

bioRxiv · Aug 8, 2023 · PreprintCell Biology

The transcription factors TFEB and TFE3 link the FLCN-AMPK signaling axis to innate immune response and pathogen resistance

L. El-Houjeiri, E. Possik, T. Tarika Vijayaraghavan, M. Paquette, J. A. Martina, J. M. Kazan, E. H. Ma, R. Jones, P. Blanchette, R. Puertollano, A. Pause

This study identifies a conserved mechanism linking FLCN-AMPK signaling to TFEB/TFE3 activation, enhancing innate immunity and pathogen resistance across species.

bioRxiv · Nov 6, 2018Immunology

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

C. H. Choy, G. Saffi, M. A. Gray, C. Wallace, R. M. Dayam, Z.-Y. A. Ou, G. Lenk, R. Puertollano, S. C. Watkins, R. J. Botelho

This study shows that PIKfyve inhibition causes lysosome coalescence, leading to fewer enlarged lysosomes, and that TFEB-mediated biosynthesis does not drive this swelling.

bioRxiv · Apr 5, 2018Cell Biology