M. Patel

This study identifies Ro 08-2750 as a small molecule that targets MSI2 RNA-binding activity, inducing differentiation, apoptosis, and reduced disease burden in AML models.

The paper describes an electronic health informatics pipeline that collects longitudinal clinical data on HBsAg and HBeAg clearance in chronic HBV infection, revealing demographic and treatment-related factors associated with clearance.

This study shows that Cry toxin production in Bacillus thuringiensis is a volunteer's dilemma, where toxin producers benefit when others also produce, but cheaters can thrive under certain conditions.

The paper identifies isoform switching between mutant IDH1 and IDH2 as a mechanism of acquired resistance to IDH inhibitors in cancers.

The paper shows that siRNAs based on CAG TNRs are toxic to cancer cells and slow tumor growth in a mouse model without toxicity.

The paper shows that many si/shRNAs targeting CD95 or CD95L induce cancer cell death via an off-target mechanism called DISE by eliminating survival genes.

The paper identifies DISE-inducing shRNAs by testing their effects on cancer cells and shows DISE is a specific cellular response, not random off-target effects.

This study shows that DISE can be induced in ovarian cancer cells in vivo using siRNA-TLPs, leading to tumor growth reduction.