Author

M. Perni

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biophysics· 3

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1

Frequent Co-Authors

M. Vendruscolo· 3 shared C. M. Dobson· 2 shared A. De Simone· 1 shared A. J. Haack· 1 shared B. Mannini· 1 shared C. Camilloni· 1 shared C. F. Kaminski· 1 shared C. Poudel· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiophysics

M. Vendruscolo

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Author profile →

3 papers

Recent·Most cited

Vitamin A and vitamin E metabolites comodulate amyloid-β aggregation

P. Joshi, S. Chia, X. Yang, M. Perni, J. Habchi, M. Vendruscolo

This study identifies retinoic acid and tocopherol as vitamin metabolites that modulate amyloid-β aggregation in vitro and in a C. elegans model, with combined effects that may cancel each other.

bioRxiv · Oct 30, 2021 · PreprintBiophysics

Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

G. T. Heller, F. A. Aprile, T. C. Michaels, R. Limbocker, M. Perni, F. S. Ruggeri, B. Mannini, T. Lohr, M. Bonomi, C. Camilloni, A. De Simone, I. C. Felli, R. Pierattelli, T. P. Knowles, C. M. Dobson, M. Vendruscolo

This paper identifies a small molecule that binds and sequesters monomeric amyloid-β, inhibiting its aggregation and rescuing toxicity in a C. elegans model.

bioRxiv · Sep 16, 2020Biophysics

Fast fluorescence lifetime imaging reveals the aggregation processes of α-synuclein and polyglutamine in aging Caenorhabditis elegans

R. F. Laine, T. Sinnige, K. Y. Ma, A. J. Haack, C. Poudel, P. Gaida, N. Curry, M. Perni, E. A. A. Nollen, C. M. Dobson, M. Vendruscolo, G. S. Kaminski Schierle, C. F. Kaminski

This study uses fast TG-FLIM to analyze α-synuclein and polyglutamine aggregation in aging C. elegans, revealing differences in their aggregation kinetics and amyloid-like features.

bioRxiv · Nov 16, 2018Biophysics