Author

F. S. Ruggeri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 8 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. Vendruscolo· 7 shared T. Knowles· 5 shared A. M. Miller· 3 shared S. Chia· 3 shared S. Qamar· 3 shared Y. Shen· 3 shared A. Kamada· 2 shared C. M. Dobson· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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7 shared papersBiophysics

M. Vendruscolo

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates

A. Miller, Z. Toprakcioglu, S. Qamar, P. St.George-Hyslop, F. S. Ruggeri, T. P. J. Knowles, M. Vendruscolo

This study characterizes the aging behavior of FUS condensates using microfluidic technology and surface-based techniques, revealing phase transitions and structural changes associated with material properties.

bioRxiv · Dec 21, 2023Biophysics

Maturation-dependent changes in the structure and seeding capacity of Aβ42 amyloid fibrils

A. M. Miller, S. Chia, E. Klimont, T. Knowles, M. Vendruscolo, F. S. Ruggeri

This study investigates how Aβ42 amyloid fibrils change over time, showing increased length, thickness, and cross-β sheet content, which affects their ability to seed new aggregates.

bioRxiv · Apr 11, 2023 · PreprintBiophysics

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes

J. Nixon-Abell, F. S. Ruggeri, S. Qamar, T. W. Herling, M. A. Czekalska, Y. Shen, G. Wang, C. King, M. S. Fernandopulle, T. Sneideris, J. L. Watson, V. V. Pillai, W. Meadows, J. Henderson, J. E. Chambers, , P. St George Hyslop

This study shows ANXA11 biomolecular condensates couple protein and lipid phase states on lysosomal membranes through interactions with ALG2 and CALC.

bioRxiv · Mar 22, 2023Cell Biology

Solid/liquid coexistence during aging of FUS condensates

Y. Shen, A. Chen, W. Wang, Y. Shen, F. S. Ruggeri, S. Aime, Z. Wang, S. S. Qamar, J. R. Espinosa, A. Garaizar Suarez, P. St George-Hyslop, R. Collepardo-Guevara, D. Weitz, D. Vigolo, T. Knowles

The paper shows that FUS condensates during aging exhibit solid/liquid coexistence, with the transition initiated at the interface between dense and dilute phases.

bioRxiv · Aug 15, 2022Biophysics

Enhanced surface nano-analytics of transient biomolecular processes

A. M. Miller, S. Chia, Z. Toprakcioglu, T. Hakala, R. Schmid, Y. Feng, T. Kartanas, A. Kamada, M. Vendruscolo, F. S. Ruggeri, T. P. J. Knowles

This paper develops a lab-on-a-chip method for analyzing biomolecular processes with high sensitivity and single molecule resolution in physiological conditions.

bioRxiv · Jul 25, 2022 · PreprintBiophysics

The Hsc70 Disaggregation Machinery RemovesMonomer Units Directly from α-Synuclein FibrilEnds

M. M. Schneider, S. Gautam, T. W. Herling, E. Andrzejwska, G. Krainer, A. M. Miller, Q. A. E. Peter, F. S. Ruggeri, M. Vendruscolo, A. Bracher, C. M. Dobson, F.-U. Hartl, T. Knowles

This study shows the Hsc70-DnaJB1-Apg2 chaperone system removes monomer units directly from α-synuclein fibril ends, reversing aggregation without intermediate fragmentation.

bioRxiv · Nov 2, 2020Biophysics

Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

G. T. Heller, F. A. Aprile, T. C. Michaels, R. Limbocker, M. Perni, F. S. Ruggeri, B. Mannini, T. Lohr, M. Bonomi, C. Camilloni, A. De Simone, I. C. Felli, R. Pierattelli, T. P. Knowles, C. M. Dobson, M. Vendruscolo

This paper identifies a small molecule that binds and sequesters monomeric amyloid-β, inhibiting its aggregation and rescuing toxicity in a C. elegans model.

bioRxiv · Sep 16, 2020Biophysics

Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition

Y. Shen, F. S. Ruggeri, D. Vigolo, A. Kamada, S. Qamar, A. Levin, C. Iserman, S. Alberti, P. St George-Hyslop, T. Knowles

The paper shows that protein condensates undergo a liquid-to-solid transition under mechanical shear, revealing hydrogen bonding as a key factor.

Nature Nanotechnology · Jul 13, 2020Peer-reviewedBiophysics

Infrared Nanospectroscopy Reveals the Molecular Interaction Fingerprint of an Aggregation Inhibitor with Single Aβ42 Oligomers

F. S. Ruggeri, J. Habchi, S. Chia, M. Vendruscolo, T. Knowles

This study uses infrared nanospectroscopy to directly measure how bexarotene interacts with Aβ42 oligomers and fibrils, revealing a single hydrogen bond between the compound's carbonyl group and the aggregates.

bioRxiv · Jun 24, 2020Biophysics