Author

M. R. Firpo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

B. C. Mounce· 2 shared A. Jaochimiak· 1 shared B. C. Dickinson· 1 shared B. Schuster· 1 shared C. B. Brooke· 1 shared E. A. Bruce· 1 shared G. Randall· 1 shared H. M. Froggatt· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

B. C. Mounce

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Author profile →

2 papers

Recent·Most cited

Polyamines and eIF5A hypusination facilitate SREBP2 translation and cholesterol synthesis to enhance enterovirus attachment and infection

M. R. Firpo, M. J. Petite, N. J. LoMascolo, P. Shah, B. C. Mounce

This study shows polyamines enhance CVB3 infection by promoting SREBP2 translation and cholesterol synthesis, linking polyamine and cholesterol homeostasis.

bioRxiv · Nov 1, 2021 · PreprintMicrobiology

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

N. Drayman, K. A. Jones, S.-A. Azizi, H. M. Froggatt, K. Tan, N. Ivanova Maltseva, S. Chen, V. Nicolaescu, S. Dvorkin, K. Furlong, R. S. Kathayat, M. R. Firpo, V. Mastrodomenico, E. A. Bruce, M. M. Schmidt, , S. Tay

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

bioRxiv · Aug 31, 2020Microbiology