S. Dvorkin

Cellular RNA interacts with MAVS to promote antiviral signaling

The paper shows that cellular RNA interacts with MAVS to scaffold signaling proteins and promote antiviral signaling by facilitating IRF3 phosphorylation.

Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity

This study develops a subunit nanovaccine using polymersomes decorated with SARS-CoV-2 RBD, showing enhanced neutralizing antibody and T cell responses in mice.

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

This paper demonstrates that conjugating the SARS-CoV-2 Spike protein to a polymeric glyco-adjuvant elicits strong cellular and humoral immune responses in mice.

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

Autoencoder based local T cell repertoire density can be used to classify samples and T cell receptors

The paper introduces ELATE, an autoencoder-based method to estimate local T cell repertoire density, enabling classification of samples and prediction of TCR-peptide binding.

CDR3 and V- genes show distinct reconstitution patterns in T-cell repertoire post allogenic bone marrow transplantation

The paper tracks T-cell repertoire changes post allogeneic bone marrow transplantation, finding that CDR3 sequences remain donor-derived while V-gene usage shifts toward the recipient over time.

Prediction of specific TCR-peptide binding from large dictionaries of TCR-peptide pairs

The paper introduces ERGO, a TCR-peptide binding predictor using NLP and deep learning, which outperforms existing methods in multiple benchmark tests.