M. R. King

Single fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates

This study uses single-fluorogen imaging to reveal that biomolecular condensates have hydrophobic internal environments and spatially inhomogeneous molecular organization.

Dynamical control enables the formation of demixed biomolecular condensates

This study identifies dynamical control as a mechanism enabling the formation of demixed biomolecular condensates by showing that asynchronous molecular production is required for their coexistence.

RanGTP regulates the augmin complex

The paper shows that RanGTP directly regulates the augmin complex, which is a spindle assembly factor, to control branching microtubule nucleation during mitosis.

Uncovering molecular grammars of intrinsically disordered regions that organize nucleolar fibrillar centers

The paper identifies molecular grammars in intrinsically disordered regions of nucleolar proteins that drive phase separation to form nucleolar substructures.

The soluble N-termini of mechanosensitive ion channels MSL8, MSL9, and MSL10 are environmentally sensitive intrinsically disordered regions with distinct biophysical characteristics

This study identifies and characterizes intrinsic disorder in the N-terminal domains of MSL8, MSL9, and MSL10, showing distinct biophysical properties and environmental responsiveness.

Acentrosomal spindles assemble from branching microtubule nucleation near chromosomes

The paper shows that chromosomes can nucleate microtubules to form spindles without centrosomes, using branching nucleation near kinetochores.

Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus ends

The paper shows that multivalent interactions enable motor-dependent protein accumulation at microtubule ends through disordered networks and liquid droplet formation in a reconstituted fission yeast system.

Oxaliplatin Resistance in Colorectal Cancer Enhances TRAIL Sensitivity Via Death Receptor 4 Upregulation and Lipid Raft Localization

This study shows oxaliplatin-resistant colorectal cancer cells become more sensitive to TRAIL due to increased DR4 expression, palmitoylation, and lipid raft localization.

Branching microtubule nucleation is controlled by importin-mediated inhibition of TPX2 phase separation

This study shows that importin-mediated interactions inhibit TPX2 phase separation, thereby regulating branching microtubule nucleation during spindle assembly.

Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation

The paper shows TPX2 phase separates with tubulin to enhance and spatially coordinate microtubule nucleation in vitro and in cytosol.