I. Seim

Biomolecular condensates in fungi are tuned to function at specific temperatures

The paper shows that temperature affects the material properties of Whi3 condensates in fungi, which are optimized by sequence changes for specific climates.

Sirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder Afrotheria

This study analyzes sirenian genomes to identify genomic adaptations to aquatic life and conservation challenges.

Evolutionary transcriptomics reveals longevity mostly driven by polygenic and indirect selection in mammals

This study uses comparative transcriptomics across mammals to show that longevity is influenced by polygenic and indirect selection, with key pathways like insulin signaling showing correlations with lifespan.

Dynamical control enables the formation of demixed biomolecular condensates

This study identifies dynamical control as a mechanism enabling the formation of demixed biomolecular condensates by showing that asynchronous molecular production is required for their coexistence.

Diversity, function and evolution of marine microbe genomes

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

Membrane surfaces regulate assembly of a ribonucleoprotein condensate

The paper shows membrane surfaces control the size and position of ribonucleoprotein condensates by altering diffusion rates of proteins and nucleic acids.

A gene duplication of a septin provides a developmentally-regulated filament length control mechanism

The paper identifies a gene duplication in Ashbya gossypii that generates two septin proteins with distinct biophysical properties and developmental regulation.

Dilute phase oligomerization can oppose phase separation and modulate material properties of a ribonucleoprotein condensate

This study shows that a specific sequence motif in the Whi3 protein promotes dilute phase oligomerization, which opposes phase separation and alters the composition and material properties of ribonucleoprotein condensates.

Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging

This paper uses a polymer model to show that spatial patterning of LLPS-promoting and solubilizing elements in SARS-CoV-2 RNA supports genome packaging, compaction, and cyclization without requiring a single packaging signal.

The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype

This study identifies GHSROS, a lncRNA upregulated in prostate cancer, which promotes aggressive tumor traits and may be a therapeutic target.

Contraction of the ROS scavenging enzyme glutathione S-transferase gene family in cetaceans

This study examines the evolution of the glutathione S-transferase gene family in cetaceans, finding lineage-specific gene losses and positive selection, suggesting adaptation to aquatic environments.

Recent origin of an XX/XY sex-determination system in the ancient plant lineage Ginkgo biloba

The paper resolves the sex-determination system in Ginkgo biloba, identifying XY chromosomes and five potential sex-determination genes originating ~14 million years ago.

Comparative genomics reveals contraction in cytosolic glutathione transferase genes in cetaceans: implications for oxidative stress adaptation

This study investigates the molecular evolution of glutathione transferase (GST) genes in cetaceans, finding gene loss and adaptive evolution linked to oxidative stress adaptation.

No effect of administration of unacylated ghrelin on subcutaneous PC3 xenograft growth in a Rag1-/- mouse model of metabolic dysfunction

This study investigates the effect of unacylated ghrelin on PC3 xenograft growth in Rag1-/- mice with metabolic dysfunction, finding no effect on tumor growth but improved glucose tolerance.