M. D. Vahey

Genetically recoding respiratory syncytial virus to visualize nucleoprotein dynamics and virion assembly

This study genetically recodes respiratory syncytial virus to label its nucleoprotein, revealing pathways for viral assembly.

Antibody inhibition of influenza A virus assembly and release

This study investigates how antibodies inhibit influenza A virus assembly and release, finding that some antibodies restrict viral egress at higher concentrations than entry inhibition and alter virion morphology.

Uncovering molecular grammars of intrinsically disordered regions that organize nucleolar fibrillar centers

The paper identifies molecular grammars in intrinsically disordered regions of nucleolar proteins that drive phase separation to form nucleolar substructures.

Neuraminidase activity modulates cellular co-infection during influenza A virus multicycle growth

This study identifies neuraminidase activity as a factor controlling cellular co-infection during influenza A virus growth, showing it modulates viral spread by affecting receptor availability.

Six-Dimensional Single-Molecule Imaging with Isotropic Resolution using a Multi-View Reflector Microscope

The paper introduces a raMVR microscope that achieves 6D super-resolution imaging of single molecules with high precision in 3D position and orientation.

A morphological transformation in respiratory syncytial virus leads to enhanced complement activation

This study identifies how morphological changes in RSV particles enhance complement activation through specific antigenic and biophysical features.

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

The paper identifies CH25H and its product 25HC as inhibitors of SARS-CoV-2 replication by blocking membrane fusion.

Influenza A virus surface proteins are organized to help penetrate host mucus

This study shows that influenza A virus surface proteins are asymmetrically organized to enable directional movement through mucus while maintaining cell attachment.

Low fidelity assembly of influenza A virus promotes escape from host cells

This study shows that influenza A virus produces morphologically and compositionally variable virions, which help it survive environmental challenges through low fidelity assembly.

Claudin-4 Reconstituted in Unilamellar Vesicles is Sufficient to Form Tight Interfaces that Partition Membrane Proteins

This study shows that claudin-4 reconstituted in vesicles forms tight interfaces that partition membrane proteins, supporting its role as a molecular fence in epithelial polarization.