Author

A. Valvezan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

A. Amalric· 1 shared A. M. Hosios· 1 shared A. N. Grumet· 1 shared A. R. Cole· 1 shared A. Uboveja· 1 shared B. D. Manning· 1 shared B. Yang· 1 shared C. Happe· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. Amalric

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Author profile →

2 papers

Recent·Most cited

ATR promotes mTORC1 activity via de novo cholesterol synthesis

N. K. Tangudu, A. N. Grumet, R. Fang, R. Buj, A. R. Cole, A. Uboveja, A. Amalric, B. Yang, Z. Huang, C. Happe, M. Sun, S. L. Gelhaus, M. L. MacDonald, N. Hempel, N. W. Snyder, , K. M. Aird

This study shows ATR enhances mTORC1 activity through cholesterol synthesis via LSS, independent of CHK1 and TSC, and this effect is amplified in p16-deficient cells.

bioRxiv · Oct 27, 2023Cell Biology

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

M. E. Torrence, M. R. MacArthur, A. M. Hosios, A. Valvezan, J. M. Asara, J. R. Mitchell, B. D. Manning

This study shows that mTORC1 activates ATF4 to promote protein and glutathione synthesis, distinct from ISR-mediated ATF4 activation.

bioRxiv · Oct 3, 2020Cell Biology