Author

M. R. Markovetz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

D. B. Hill· 6 shared K. R. Rouillard· 3 shared L. M. Plott· 3 shared B. Button· 2 shared C. B. Morrison· 2 shared C. Ehre· 2 shared M. Kesimer· 2 shared R. Freeman· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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6 shared papersMicrobiology

D. B. Hill

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Clostridioides difficile-mucus interactions encompass shifts in gene expression, metabolism, and biofilm formation

K. L. Furtado, L. M. Plott, M. R. Markovetz, D. A. Powers, H. Wang, D. B. Hill, J. A. Papin, N. L. Allbritton, R. Tamayo

This study investigates how C. difficile uses host-derived mucus for growth, metabolism, and biofilm formation, revealing metabolic shifts and potential pathogenic mechanisms.

mSphere · Jun 25, 2024Peer-reviewedMicrobiology

Mucus polymer concentration and in vivo adaptation converge to define the antibiotic response of Pseudomonas aeruginosa during chronic lung infection

M. A. Greenwald, S. L. Meinig, L. M. Plott, C. Roca, M. G. Higgs, N. P. Vitko, M. R. Markovetz, K. R. Rouillard, J. Carpenter, M. Kesimer, D. B. Hill, J. C. Schisler, M. C. Wolfgang

This study shows that increased mucin and eDNA concentrations in mucus enhance Pseudomonas aeruginosa antibiotic tolerance, and establishes an in vitro model to replicate this tolerance observed in sputum.

bioRxiv · Dec 20, 2023 · PreprintMicrobiology

Statistical Methods for Microrheology of Airway Mucus with Extreme Heterogeneity

N. Caughman, M. Papanikolas, M. R. Markovetz, R. Freeman, D. B. Hill, M. G. Forest, M. Lysy

This paper develops statistical methods to analyze rheological heterogeneity in CF-related airway mucus using particle-tracking and noise decomposition.

bioRxiv · Nov 20, 2023 · PreprintMicrobiology

Combination Treatment to Improve Mucociliary Transport of Pseudomonas aeruginosa Biofilms

K. R. Rouillard, C. P. Esther, W. Kissner, L. M. Plott, D. W. Bowman, M. R. Markovetz, D. B. Hill

This paper tests combination treatments to disrupt Pseudomonas aeruginosa biofilms in mucus, finding that NP40, hyaluronic acid, and tobramycin most effectively increase mucociliary transport and reduce bacterial viability.

bioRxiv · Aug 14, 2023 · PreprintMicrobiology

Effects of mucin and DNA concentrations in airway mucus on Pseudomonas aeruginosa biofilm recalcitrance

K. R. Rouillard, W. J. Kissner, M. R. Markovetz, D. Hill

This study investigates how mucin and DNA concentrations in airway mucus affect Pseudomonas aeruginosa biofilm mechanical properties, finding that overall mucus concentration is the main factor influencing viscoelasticity.

bioRxiv · Mar 24, 2022Microbiology

Hyperconcentrated Mucus Unifies Submucosal Gland and Superficial Airway Dysfunction in Cystic Fibrosis

T. Kato, G. Radicioni, M. J. Papanikolas, G. V. Stoychev, M. R. Markovetz, K. Aoki, M. Porterfield, K. Okuda, S. M. B. Cardenas, R. C. Gilmore, C. B. Morrison, C. Ehre, K. A. Burns, K. K. White, T. A. Brennan, , R. C. Boucher

This study identifies hyperconcentrated mucus as a unifying mechanism for submucosal gland and superficial airway dysfunction in cystic fibrosis.

bioRxiv · Sep 22, 2021 · PreprintPathology

BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance.

L. J. Donoghue, M. R. Markovetz, C. B. Morrison, K. M. McFadden, T. D. Rogers, B. Button, C. Ehre, D. B. Hill, B. R. Grubb, S. N. P. Kelada

This study shows that BPIFB1 loss in mice impairs mucociliary clearance by altering mucus viscosity without affecting ion transport or ciliary beat frequency.

bioRxiv · Jun 17, 2020Physiology