R. Freeman

Charge distribution and helical content tune the binding of septins amphipathic helix domain to lipid membranes

This study investigates how charge distribution and helical content of amphipathic helix domains affect septin binding to lipid membranes using simulations and experiments.

Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophy

This study shows that cardiomyocyte PGC-1α is essential for cardiac adaptation to endurance exercise by suppressing GDF15 and preventing cardiac atrophy in mice.

Statistical Methods for Microrheology of Airway Mucus with Extreme Heterogeneity

This paper develops statistical methods to analyze rheological heterogeneity in CF-related airway mucus using particle-tracking and noise decomposition.

Nonequilibrium bending fluctuations reveal microtubule mechanics in-vivo and their regulation by glutamylation

The paper measures microtubule mechanics in living cells using motor-generated forces and shows that polyglutamylation increases microtubule stiffness.

How much data do we need? Reliability and data deficiency in global vertebrate biodiversity trends

This study assesses the reliability of global vertebrate biodiversity trends by simulating data deficiency and identifying factors affecting trend accuracy.

Biodiversity shows unique responses to land-use change across regional biomes

This study identifies regional biomes as a better scale than biomes or realms alone to capture variation in biodiversity responses to land-use change, with consistent negative effects in tropical forests.

SCCA1/SERPINB3 promotes suppressive immune environment via STAT-dependent chemokine production, blunting the therapy-induced T cell responses

This study shows that SCCA1/SERPINB3 promotes an immunosuppressive tumor microenvironment by increasing chemokine production via STAT signaling, reducing T cell responses to radiotherapy.

Recovering birds and mammals across Europe continue to be negatively impacted by threats but benefit from conservation measures

The paper examines recovery trends of 47 European bird and mammal species, finding that greater threat diversity reduces recovery likelihood but conservation measures can mitigate this effect.

Past, present, and future of the Living Planet Index

The paper reviews the evolution of the Living Planet Index, its role in biodiversity monitoring, and its findings of a 68% global vertebrate population decline between 1970 and 2016.

A user-friendly guide to using distance measures to compare time series in ecology.

This paper introduces a method to select appropriate distance measures for comparing ecological time series, demonstrating it on UK bird population data.

Modeling predicts mechanisms altered by mutations of the SARS-CoV-2 delta and omicron variants

The paper models how mutations in SARS-CoV-2 delta and omicron variants alter viral load and infection outcomes by simulating different mechanistic changes.

Body mass and latitude as global predictors of vertebrate populations exposure to multiple threats

Hyperconcentrated Mucus Unifies Submucosal Gland and Superficial Airway Dysfunction in Cystic Fibrosis

This study identifies hyperconcentrated mucus as a unifying mechanism for submucosal gland and superficial airway dysfunction in cystic fibrosis.

A Programmable Toolkit to Dynamically Signal Cells using Peptide Strand Displacement

This paper introduces a synthetic platform using coiled-coil peptides to dynamically display cell adhesive signals and studies how temporal ligand exposure affects cell spreading and integrin dynamics.

Body mass and latitude predict the presence of multiple stressors in global vertebrate populations

The paper identifies body mass and latitude as predictors of multiple stressor presence in global vertebrate populations, showing varying trends across ecosystems and species.

A global indicator of utilised wildlife populations: regional trends and the impact of management

The paper analyzes global wildlife population trends, showing utilised populations decline faster than non-utilised ones, and finds management can improve trends for utilised species.

The Species Awareness Index (SAI): a Wikipedia-derived conservation culturomics metric for public biodiversity awareness

The paper introduces the Species Awareness Index (SAI) to measure public biodiversity awareness using Wikipedia data, finding increasing awareness overall but varying by taxonomic class and language.

Multivalent Clustering of Adhesion Ligands in Nanofiber-Nanoparticle Composites

This study demonstrates that clustering bioactive signals on silica nanoparticles enhances fibroblast adhesion on composite hydrogels compared to peptide amphiphile-only matrices.

Comparative physiology of five tropical montane songbirds reveals differential seasonal acclimatisation and cold adaption

This study compares seasonal physiological changes in five tropical montane songbirds, finding species-specific metabolic adjustments and cold tolerance in one high-elevation species.

Bat Detective - Deep Learning Tools for Bat Acoustic Signal Detection

This paper develops and evaluates open-source deep learning tools for detecting bat echolocation calls in noisy audio recordings, showing improved performance over existing methods.