Author

M. R. Steensma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:rat· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

C. R. Graveel· 5 shared C. J. Essenburg· 4 shared E. A. Tovar· 4 shared P. S. Dischinger· 4 shared L. Turner· 3 shared C. R. Esquibel· 2 shared I. Beddows· 2 shared K. Feenstra· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCancer Biology

C. R. Graveel

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

NF1 deficiency drives metabolic reprogramming in ER+ breast cancer

R. J. House, E. A. Tovar, C. J. Essenburg, P. S. Dischinger, A. E. Ellis, I. Beddows, R. D. Sheldon, E. C. Lien, C. R. Graveel, M. R. Steensma

This study investigates how NF1 deficiency affects metabolic reprogramming in ER+ breast cancer and identifies potential therapeutic synergies between metabolic and targeted inhibitors.

bioRxiv · Nov 24, 2023 · PreprintCancer Biology

Nf1 Deficiency Increases Mammary Collagen Deposition and Restricts Adipocyte Differentiation Before Tumor Formation

M. Arumugam, E. A. Tovar, C. J. Essenburg, P. S. Dischinger, I. T. Beddows, E. Wolfrum, Z. B. Madaj, L. Turner, K. Feenstra, K. L. Gallik, L. Cohen, M. Nichols, R. T. Sheridan, C. R. Esquibel, G. Mouneimne, , M. R. Steensma

This study shows that Nf1 deficiency in rats increases mammary collagen and restricts adipocyte differentiation before tumor formation, suggesting a role in breast cancer risk.

bioRxiv · Jun 1, 2023 · PreprintCancer Biology

Nf1 deficiency accelerates mammary development and promotes luminal-basal plasticity

E. A. Tovar, M. Arumugam, C. J. Essenburg, P. S. Dischinger, J. L. Grit, M. Callaghan, R. T. C. Sheridan, L. Turner, C. R. Esquibel, K. Feenstra, Z. Madaj, I. Beddows, C. R. Graveel, M. R. Steensma

This study shows that Nf1 deficiency in rats accelerates mammary development and promotes luminal-basal plasticity and EMT-mediated invasion.

bioRxiv · Dec 22, 2022 · PreprintCancer Biology

Reciprocal inflammatory signaling in an ex-vivo explant model for neurofibromatosis type 1-related cutaneous neurofibromas

J. Grit, L. Turner, C. Essenburg, P. Dischinger, N. Shurlow, M. Pate, C. R. Graveel, M. R. Steensma

This study develops an ex vivo explant model of neurofibromas from NF patients, revealing reciprocal inflammatory signaling pathways and demonstrating glucocorticoid treatment's effect on inflammation.

bioRxiv · Oct 6, 2022 · PreprintCell Biology

NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer

P. S. Dischinger, E. A. Tovar, C. J. Essenburg, Z. B. Madaj, E. E. Gardner, M. Callaghan, A. N. Turner, A. K. Challa, T. Kempston, B. Eagleson, R. A. Kesterson, R. T. Bronson, M. J. Bowman, C. R. Graveel, M. R. Steensma

This study shows NF1 deficiency in breast cancer correlates with estrogen receptor signaling and poor survival, using rat models and human genomic data.

bioRxiv · Feb 27, 2018Cancer Biology