M. Arumugam

Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations

This study shows that fecal microbial load, not disease, is the main driver of gut microbiome changes and identifies it as a major confounder in microbiome studies.

Zinc Alpha-2-Glycoprotein (ZAG/AZGP1) secreted by triple-negative breast cancer promotes tumor microenvironment fibrosis.

This study identifies ZAG/AZGP1 as a secreted factor from triple-negative breast cancer cells that promotes fibrosis in the tumor microenvironment and is linked to poor patient prognosis.

Nf1 Deficiency Increases Mammary Collagen Deposition and Restricts Adipocyte Differentiation Before Tumor Formation

This study shows that Nf1 deficiency in rats increases mammary collagen and restricts adipocyte differentiation before tumor formation, suggesting a role in breast cancer risk.

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs

This study shows p53 loss in NF1-related MPNSTs leads to MET instability, kinome reprogramming, and therapy resistance through altered signaling and lineage plasticity.

Nf1 deficiency accelerates mammary development and promotes luminal-basal plasticity

This study shows that Nf1 deficiency in rats accelerates mammary development and promotes luminal-basal plasticity and EMT-mediated invasion.

Butyrate producing Clostridiales utilize distinct human milk oligosaccharides correlating to early colonization and prevalence in the human gut

The paper identifies HMO utilization pathways in Roseburia and Eubacterium that enable co-growth with Akkermansia muciniphilia and highlight distinct HMO utilization phylotypes in the early gut microbiota.