Author

C. R. Graveel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5 Cell Biology· 1

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:rat· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2

Frequent Co-Authors

C. J. Essenburg· 5 shared E. A. Tovar· 5 shared M. R. Steensma· 5 shared P. S. Dischinger· 4 shared I. Beddows· 3 shared L. Turner· 3 shared M. Arumugam· 3 shared C. R. Esquibel· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

C. J. Essenburg

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Author profile →

6 papers

Recent·Most cited

NF1 deficiency drives metabolic reprogramming in ER+ breast cancer

R. J. House, E. A. Tovar, C. J. Essenburg, P. S. Dischinger, A. E. Ellis, I. Beddows, R. D. Sheldon, E. C. Lien, C. R. Graveel, M. R. Steensma

This study investigates how NF1 deficiency affects metabolic reprogramming in ER+ breast cancer and identifies potential therapeutic synergies between metabolic and targeted inhibitors.

bioRxiv · Nov 24, 2023 · PreprintCancer Biology

Nf1 Deficiency Increases Mammary Collagen Deposition and Restricts Adipocyte Differentiation Before Tumor Formation

M. Arumugam, E. A. Tovar, C. J. Essenburg, P. S. Dischinger, I. T. Beddows, E. Wolfrum, Z. B. Madaj, L. Turner, K. Feenstra, K. L. Gallik, L. Cohen, M. Nichols, R. T. Sheridan, C. R. Esquibel, G. Mouneimne, , M. R. Steensma

This study shows that Nf1 deficiency in rats increases mammary collagen and restricts adipocyte differentiation before tumor formation, suggesting a role in breast cancer risk.

bioRxiv · Jun 1, 2023 · PreprintCancer Biology

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs

J. L. Grit, L. E. McGee, E. A. Tovar, C. J. Essenburg, E. Wolfrum, I. Beddows, K. Williams, R. Sheridan, J. Schipper, M. Adams, M. Arumugam, T. Vander Woude, S. Gurunathan, J. M. Field, J. Wulfkuhle, , M. Steensma

This study shows p53 loss in NF1-related MPNSTs leads to MET instability, kinome reprogramming, and therapy resistance through altered signaling and lineage plasticity.

bioRxiv · Jan 18, 2023Cancer Biology

Nf1 deficiency accelerates mammary development and promotes luminal-basal plasticity

E. A. Tovar, M. Arumugam, C. J. Essenburg, P. S. Dischinger, J. L. Grit, M. Callaghan, R. T. C. Sheridan, L. Turner, C. R. Esquibel, K. Feenstra, Z. Madaj, I. Beddows, C. R. Graveel, M. R. Steensma

This study shows that Nf1 deficiency in rats accelerates mammary development and promotes luminal-basal plasticity and EMT-mediated invasion.

bioRxiv · Dec 22, 2022 · PreprintCancer Biology

Reciprocal inflammatory signaling in an ex-vivo explant model for neurofibromatosis type 1-related cutaneous neurofibromas

J. Grit, L. Turner, C. Essenburg, P. Dischinger, N. Shurlow, M. Pate, C. R. Graveel, M. R. Steensma

This study develops an ex vivo explant model of neurofibromas from NF patients, revealing reciprocal inflammatory signaling pathways and demonstrating glucocorticoid treatment's effect on inflammation.

bioRxiv · Oct 6, 2022 · PreprintCell Biology

NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer

P. S. Dischinger, E. A. Tovar, C. J. Essenburg, Z. B. Madaj, E. E. Gardner, M. Callaghan, A. N. Turner, A. K. Challa, T. Kempston, B. Eagleson, R. A. Kesterson, R. T. Bronson, M. J. Bowman, C. R. Graveel, M. R. Steensma

This study shows NF1 deficiency in breast cancer correlates with estrogen receptor signaling and poor survival, using rat models and human genomic data.

bioRxiv · Feb 27, 2018Cancer Biology