Author

T. Verkerk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

R. M. Spaapen· 5 shared A. A. de Waard· 4 shared M. L. M. Jongsma· 3 shared S. Bliss· 3 shared A. H. de Ru· 2 shared A. Mulder· 2 shared A. T. Pappot· 2 shared F. H. J. Claas· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersImmunology

R. M. Spaapen

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5 papers

Recent·Most cited

Tumor-expressed SPPL3 supports innate anti-tumor immune responses.

T. Verkerk, A. A. de Waard, S. J. Koomen, J. Sanders, T. Jorritsma, A. T. Pappot, N. D. Zandhuis, T. Zhang, M. Wuhrer, H. S. J. Stockinger, K. P. J. M. van Gisbergen, R. M. Spaapen, S. M. van Ham

This study shows that SPPL3 in tumor cells affects innate immune responses by modulating nsGSLs, reducing susceptibility to neutrophils, NK cells, and γδ T cells.

bioRxiv · Apr 25, 2024 · PreprintImmunology

Isolation and expansion of pure and functional γδ T cells

T. Verkerk, A. T. Pappot, T. Jorritsma, L. A. King, R. M. Spaapen, S. M. van Ham

This study isolates and expands pure γδ T cells from blood while maintaining their anti-tumor functions, showing effective expansion and effector activity.

bioRxiv · Nov 12, 2023 · PreprintImmunology

The SPPL3-defined glycosphingolipid repertoire regulates immune responses by improving HLA class I access

M. L. M. Jongsma, M. Raaben, A. A. de Waard, T. Zhang, B. Cabukusta, R. Platzer, V. A. Blomen, A. Xagara, T. Verkerk, S. Bliss, L. Janssen, E. Stickel, S. Holst, R. Plomp, A. Mulder, , R. M. Spaapen

The paper identifies a glycosphingolipid (GSL) signature that inhibits HLA-I antigen presentation and shows its reversal by clinically approved drugs.

bioRxiv · Sep 26, 2020Immunology

Healthy cells functionally present TAP-independent SSR1 peptides: implications for selection of clinically relevant antigens

A. A. de Waard, T. Verkerk, K. Hoefakker, D. M. van der Steen, M. L. M. Jongsma, S. Bliss, A. H. de Ru, P. A. van Veelen, M. Griffioen, M. H. M. Heemskerk, R. M. Spaapen

The paper identifies TAP-independent antigen presentation in healthy cells using a T cell clone and highlights the need for comprehensive testing of healthy cell types to safely target antigens for immunotherapy.

bioRxiv · Jun 11, 2020Immunology

PAKC: A novel Panel of HLA class I Antigen presentation machinery Knockout Cells from the same genetic origin

A. A. de Waard, T. Verkerk, M. L. M. Jongsma, K. Hoefakker, S. Sethumadhavan, C. Gerke, S. Bliss, G. M. C. Janssen, A. H. de Ru, F. H. J. Claas, A. Mulder, R. Tampe, P. A. van Veelen, A. Halenius, R. M. Spaapen

The paper generates a panel of APM knockout cell lines to study HLA class I antigen presentation and its role in immune responses.

bioRxiv · Jan 24, 2020Immunology