R. M. Spaapen

Isolation and expansion of pure and functional γδ T cells

This study isolates and expands pure γδ T cells from blood while maintaining their anti-tumor functions, showing effective expansion and effector activity.

Soluble FAS Ligand directs human memory B cells towards antibody-secreting cells

This study identifies soluble FAS ligand as a factor promoting memory B cell differentiation into antibody-secreting cells, linking it to autoimmunity and potential therapeutic targets.

The SPPL3-defined glycosphingolipid repertoire regulates immune responses by improving HLA class I access

The paper identifies a glycosphingolipid (GSL) signature that inhibits HLA-I antigen presentation and shows its reversal by clinically approved drugs.

Healthy cells functionally present TAP-independent SSR1 peptides: implications for selection of clinically relevant antigens

The paper identifies TAP-independent antigen presentation in healthy cells using a T cell clone and highlights the need for comprehensive testing of healthy cell types to safely target antigens for immunotherapy.

T cells expanded from renal cell carcinoma are tumor-reactive but fail to produce IFN-γ, TNF-α or IL-2

The paper examines TILs from RCC patients, finding that while some are tumor-reactive, they fail to produce key cytokines in response to autologous tumors.

PAKC: A novel Panel of HLA class I Antigen presentation machinery Knockout Cells from the same genetic origin

The paper generates a panel of APM knockout cell lines to study HLA class I antigen presentation and its role in immune responses.

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

The paper isolates and expands tumor-reactive T cells from NSCLC tumors, finding that polyfunctional T cells correlate with immune-engaged T cell profiles and tumor reactivity.