S. K. Mageswaran

Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

This study identifies caspase-1 and GSDMD as key mediators of inflammasome responses that restrict Salmonella replication in human macrophages.

In situ structure and priming mechanism of the rhoptry secretion system in Plasmodium revealed by cryo-electron tomography

This study uses cryo-electron tomography to reveal the structure and priming mechanism of the rhoptry secretion system in Plasmodium falciparum merozoites, identifying distinct organizational states and conformational changes in the RSA.

Nanoscale details of mitochondrial fission revealed by cryo-electron tomography

This study uses cryo-electron tomography to reveal nanoscale details of mitochondrial fission in mammalian cells, showing coordinated membrane constriction and the role of actin and septin filaments.

Plasma membrane damage removal by F-actin-mediated shedding from repurposed filopodia

The paper uses electron cryotomography to show that filopodia-like protrusions mediate plasma membrane damage repair through F-actin dynamics and ESCRT components.

Distinguishing Signal From Autofluorescence In Cryogenic Correlated Light And Electron Microscopy Of Mammalian Cells

The paper develops a method to distinguish fluorescent signals from autofluorescence in cryo-CLEM of mammalian cells using spectral differences.