L. Stiles

Pro-inflammatory macrophage activation does not require inhibition of mitochondrial respiration

This study shows that reduced oxidative phosphorylation is not required for pro-inflammatory macrophage activation, challenging the conventional model of mitochondrial reprogramming.

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis

The paper shows BT2 acts as a mitochondrial uncoupler, reducing ROS and lipogenesis, which may explain its therapeutic benefits in metabolic diseases.

Reduced methionine synthase (Mtr) expression creates a functional vitamin B12 deficiency that leads to uracil accumulation in mouse mitochondrial DNA

This study shows that reduced Mtr expression causes B12 deficiency, leading to uracil accumulation in mtDNA and impaired mitochondrial function in mice.

Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1

This study identifies OMA1 activators that induce apoptosis in DLBCL cells via the ATF4-ISR pathway, showing efficacy in preclinical models.

Calculation of ATP production rates using the Seahorse XF Analyzer

The paper develops a method to calculate ATP production rates from oxidative phosphorylation and glycolysis using Seahorse XF Analyzer data, enabling direct comparison of ATP sources in live cells.

Exacerbation of mitochondrial fission in human CD34+ cells halts erythropoiesis and hemoglobin biosynthesis

This study shows that excessive mitochondrial fission in human CD34+ cells disrupts erythropoiesis and hemoglobin biosynthesis by altering mitochondrial morphology and function.