Author

N. A. Kootstra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:imaging· 1

Frequent Co-Authors

M. J. van Gils· 4 shared J. L. van Hamme· 3 shared M. Bermejo-Jambrina· 3 shared R. W. Sanders· 3 shared J. Eder· 2 shared L. E. H. van der Donk· 2 shared P. J. M. Brouwer· 2 shared T. B. H. Geijtenbeek· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersImmunology

M. J. van Gils

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Author profile →

4 papers

Recent·Most cited

Antibodies against SARS-CoV-2 control complement-induced inflammatory responses to SARS-CoV-2

M. Bermejo-Jambrina, L. E. H. van der Donk, J. L. van Hamme, D. Wilflingseder, G. de Bree, M. Prins, M. de Jong, P. Nieuwkerk, M. J. van Gils, N. A. Kootstra, T. Geijtenbeek

This study shows that antibodies against SARS-CoV-2 reduce complement-induced inflammation, suggesting a role for complement in immune activation and antibody-mediated immune regulation.

bioRxiv · May 29, 2023 · PreprintImmunology

SARS-CoV-2 infection activates dendritic cells via cytosolic receptors rather than extracellular TLRs

L. E. H. van der Donk, J. Eder, J. L. van Hamme, P. J. M. Brouwer, M. Brinkkemper, A. C. van Nuenen, M. J. van Gils, R. W. Sanders, N. A. Kootstra, M. Bermejo-Jambrina, T. B. H. Geijtenbeek

This study shows SARS-CoV-2 does not activate dendritic cells via extracellular TLRs but instead relies on intracellular sensors after infecting ACE2-expressing dendritic cells.

bioRxiv · Sep 2, 2021Immunology

Infection and transmission of SARS-CoV-2 depends on heparan sulfate proteoglycans

M. Bermejo-Jambrina, J. Eder, T. M. Kaptein, J. L. van Hamme, L. C. Helgers, K. E. Vlaming, P. J. Brouwer, A. P. Vlaar, F. E. H. P. van Baarle, M. Spaargaren, G. J. de Bree, B. M. Nijmeijer, N. A. Kootstra, M. J. van Gils, R. W. Sanders, T. B. H. Geijtenbeek

This study identifies heparan sulfate proteoglycans as SARS-CoV-2 attachment receptors and shows that LMWH blocks infection and transmission.

bioRxiv · Aug 18, 2020Immunology

Afucosylated immunoglobulin G responses are a hallmark of enveloped virus infections and show an exacerbated phenotype in COVID-19

M. D. Larsen, E. L. de Graaf, M. E. Sonneveld, H. R. Plomp, F. Linty, R. Visser, M. Brinkhaus, T. Sustic, S. W. deTaeye, A. E. H. Bentlage, J. Nouta, S. Natunen, C. A. M. Koeleman, S. Sainio, N. A. Kootstra, , G. Vidarsson

The paper shows that afucosylated IgG responses are common in enveloped virus infections and are more severe in COVID-19, with implications for immune response and pathology.

bioRxiv · May 18, 2020Immunology