Author

M. T. Coughlan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Laskowski· 2 shared C. Granata· 2 shared D. A. Stroud· 2 shared K. Huynh· 2 shared N. j. Caruana· 2 shared P. J. Meikle· 2 shared A. C. Calkin· 1 shared A. E. Frazier· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

A. Laskowski

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Author profile →

3 papers

Recent·Most cited

Deep multi-omic profiling reveals extensive mitochondrial remodeling driven by glycemia in early diabetic kidney disease

C. Granata, V. Thallas-Bonke, N. j. Caruana, K. Huynh, C. X. Qin, A. Laskowski, M. Snelson, J. Anthonisz, E. Jap, G. Ramm, M. E. Cooper, P. Meikle, D. A. Stroud, R. H. Ritchie, M. T. Coughlan

This study shows that blood glucose levels directly affect mitochondrial function and metabolism in early diabetic kidney disease, with changes in proteome, metabolome, and lipidome.

bioRxiv · Oct 26, 2023 · PreprintCell Biology

SOD2 in Skeletal Muscle: New Insights from an Inducible Deletion Model

A. Zhuang, C. Yang, Y. Liu, Y. Tan, S. T. Bond, S. Walker, T. Sikora, A. Sharma, J. B. de Haan, P. J. Meikle, M. T. Coughlan, A. C. Calkin, B. G. Drew

This study deletes SOD2 in skeletal muscle of adult mice and finds no major metabolic impairment but altered lipid metabolism and mitochondrial abundance.

bioRxiv · May 20, 2021Physiology

Training-induced bioenergetic improvement in human skeletal muscle is associated with non-stoichiometric changes in the mitochondrial proteome without reorganization of respiratory chain content

C. Granata, N. J. Caruana, J. Botella, N. A. Jamnick, K. Huynh, J. Kuang, H. A. Janssen, B. Reljic, N. A. Mellett, A. Laskowski, T. L. Stait, A. E. Frazier, M. T. Coughlan, P. J. Meikle, D. R. Thorburn, , D. J. Bishop

The paper investigates training-induced mitochondrial adaptations in human skeletal muscle, finding non-stoichiometric changes in the proteome and challenging previous assumptions about bioenergetic improvements.

bioRxiv · Feb 19, 2021Cell Biology