J. Botella

Increased mitochondrial surface area and cristae density in the skeletal muscle of strength athletes

This study examines mitochondrial structural changes in strength athletes compared to untrained controls, finding increased cristae density and surface-to-volume ratio, along with transcriptomic evidence of mitochondrial biogenesis and stress responses.

Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in obesity

This study shows that amyloid beta 42 from adipose tissue impairs cardiac function in obesity by affecting mitochondrial metabolism, and that neutralizing A{beta} can prevent obesity-induced cardiac dysfunction.

Methodological considerations when assessing mitochondrial respiration and biomarkers for mitochondrial content in human skeletal muscle

This paper evaluates the reliability and reproducibility of methods for measuring mitochondrial respiration and citrate synthase activity in human skeletal muscle, identifying technical and biological variability factors.

Training-induced bioenergetic improvement in human skeletal muscle is associated with non-stoichiometric changes in the mitochondrial proteome without reorganization of respiratory chain content

The paper investigates training-induced mitochondrial adaptations in human skeletal muscle, finding non-stoichiometric changes in the proteome and challenging previous assumptions about bioenergetic improvements.

Changes in insulin resistance do not occur in parallel with changes in mitochondrial content and function in male rats

This study examines whether changes in insulin resistance in male rats on a high-fat diet correlate with mitochondrial content and function, finding no consistent association.

Transcriptomic Profiling of Skeletal Muscle Adaptations to Exercise and Inactivity

This study uses meta-analysis of 66 datasets to identify gene expression changes in skeletal muscle due to exercise and inactivity, highlighting NR4A3 as a key responsive gene.