D. J. Bishop

Fibre-specific mitochondrial protein abundance is linked to resting and post-training mitochondrial content in human muscle.

The paper examines fibre-specific mitochondrial protein abundance in human muscle before and after training, finding that most differences are linked to mitochondrial content rather than fibre-type-specific remodelling.

Methodological considerations when assessing mitochondrial respiration and biomarkers for mitochondrial content in human skeletal muscle

This paper evaluates the reliability and reproducibility of methods for measuring mitochondrial respiration and citrate synthase activity in human skeletal muscle, identifying technical and biological variability factors.

Training-induced bioenergetic improvement in human skeletal muscle is associated with non-stoichiometric changes in the mitochondrial proteome without reorganization of respiratory chain content

The paper investigates training-induced mitochondrial adaptations in human skeletal muscle, finding non-stoichiometric changes in the proteome and challenging previous assumptions about bioenergetic improvements.

Interpretation of exercise-induced changes in human skeletal muscle mRNA expression depends on the timing of the post-exercise biopsies

This study shows that the timing of post-exercise muscle biopsies significantly affects the observed mRNA expression changes, emphasizing the need for comprehensive time-course analysis in exercise research.

Changes in insulin resistance do not occur in parallel with changes in mitochondrial content and function in male rats

This study examines whether changes in insulin resistance in male rats on a high-fat diet correlate with mitochondrial content and function, finding no consistent association.

Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and circadian rhythms.

This study shows that high-intensity interval exercise mitigates sleep loss-induced impairments in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and circadian rhythms.

Transcriptomic Profiling of Skeletal Muscle Adaptations to Exercise and Inactivity

This study uses meta-analysis of 66 datasets to identify gene expression changes in skeletal muscle due to exercise and inactivity, highlighting NR4A3 as a key responsive gene.

Forty high-intensity interval training sessions blunt exercise-induced changes in the nuclear protein content of PGC-1α and p53 in human skeletal muscle

This study shows that 40 sessions of high-intensity interval training reduce exercise-induced increases in nuclear PGC-1α, p53, and related markers of mitochondrial biogenesis in human skeletal muscle.

Cycling with blood flow restriction improves performance and muscle K+ regulation and blunts the effect of antioxidant infusion in humans

This study shows that blood flow restriction during interval cycling improves exercise performance and muscle K+ regulation, with effects mediated by increased ROS scavenging and Na+,K+-ATPase isoform abundance.

A physiological drop in pH decreases mitochondrial respiration, and AMPK and Akt signalling, in L6 myocytes

This study examines how changes in pH and lactate levels affect mitochondrial function and signaling pathways in L6 myotubes.

Enhanced skeletal muscle ribosome biogenesis, yet attenuated mTORC1 and ribosome biogenesis-related signalling, following short-term concurrent versus single-mode resistance training.

This study compares ribosome biogenesis and mTORC1 signaling changes in skeletal muscle after short-term concurrent versus single-mode resistance training.

Repeated-ischaemic exercise enhances mitochondrial and ion transport gene adaptations in human skeletal muscle: Role of muscle redox state and AMPK

This study shows that repeated-ischaemic exercise increases mitochondrial and ion transport gene expression in human skeletal muscle, linked to oxidative stress and AMPK activation, but not hypoxia or lactate.

Post-exercise cold-water immersion increases Na+,K+-ATPase α2-isoform mRNA content in parallel with elevated Sp1 expression in human skeletal muscle

This study shows sprint-interval exercise increases NKA1 and β3 mRNA while decreasing β2 mRNA in human skeletal muscle, and post-exercise cold-water immersion increases NKA2 mRNA alongside Sp1 expression.