Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals the potential mechanism of action of miltefosine
T. F. dos Reis, M. A. C. Horta, A. C. Colabardini, C. M. Fernandes, L. P. Silva, R. Bastos, M. V. L. Fonseca, F. Wang, C. Martins, M. Rodrigues, C. Silva Pereira, M. Del Poeta, K. H. Wong, G. H. Goldman
This study screens 1,127 compounds against Aspergillus fumigatus, identifies miltefosine as fungicidal, and reveals RmiA as a transcription factor regulating sphingolipid biosynthesis involved in miltefosine resistance.
bioRxiv · May 19, 2021Microbiology