Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome
T. Yan, A. R. Julio, M. Villanueva, A. E. Jones, A. B. Ball, L. M. Boatner, A. C. Turmon, S. L. Yen, H. S. Desai, A. S. Divakaruni, K. M. Backus
The paper develops Cys-LoC and Cys-LOx methods to map compartment-specific cysteine oxidation states, revealing novel mitochondrial redox modifications in response to inflammation.
bioRxiv · Jan 22, 2023Biochemistry