This study shows Regnase-1 promotes tumor-initiating activity in NSCLC by suppressing the SOX2 pathway, and its inhibition reduces tumor growth and enhances anti-cancer immunity.

bioRxiv · Jul 8, 2025 · PreprintCancer Biology

Dynamics and Topology of Human Transcribed Cis-regulatory Elements

Shigeki Hirabayashi, Shruti Bhagat, Yu Matsuki, Yujiro Takegami, Takuya Uehata, Ai Kanemaru, Masayoshi Itoh, Kotaro Shirakawa, Akifumi Takaori‐Kondo, Osamu Takeuchi, Piero Carninci, Shintaro Katayama, Yoshihide Hayashizaki, Juha Kere, Hideya Kawaji, Yasuhiro Murakawa

The paper develops NET-CAGE to detect nascent RNA 5-ends, identifies enhancer-promoter pairs, and reveals topological connections of cis-regulatory elements across cell types.

bioRxiv · Jul 3, 2019 · PreprintGenomics

Codon Bias Confers Stability to mRNAs via ILF2 in Humans

Fabian Hia, Sheng Fan Yang, Yuichi Shichino, Masanori Yoshinaga, Yasuhiro Murakawa, Alexis Vandenbon, Akira Fukao, Toshinobu Fujiwara, Markus Landthaler, Tohru Natsume, Shungo Adachi, Shintaro Iwasaki, Osamu Takeuchi

The paper shows that codon bias affects mRNA stability in humans through ILF2, with GC3 codons stabilizing and AT3 codons destabilizing mRNA.

bioRxiv · Apr 4, 2019 · PreprintMolecular Biology