Young Eun Lee

Impaired SOX17 Expression Causes Endothelial Dysfunction and Pulmonary Arterial Hypertension by Insufficient Suppression of RUNX1

This study shows that impaired SOX17 expression increases pulmonary arterial hypertension risk by failing to suppress RUNX1, leading to endothelial dysfunction, and that RUNX1 inhibition can mitigate this condition.

Enabling CAR-T Cell Immunotherapy in Glioblastoma by Modifying Tumor Microenvironment via Oncolytic Adenovirus Encoding Bispecific T Cell Engager

This paper demonstrates that combining oncolytic adenovirus encoding bispecific T cell engager (OV-BiTE) with CAR-T cells enhances T cell recruitment and tumor eradication in glioblastoma xenograft models.

Myeloid Specific Ablation of SHIP1 Boosts ex vivo Expansion and Regulatory Function of Myeloid-Derived Suppressor Cells in Inflammatory Arthritis

This study shows that myeloid-specific SHIP1 ablation enhances MDSC expansion and regulatory function in inflammatory arthritis, offering potential therapeutic applications.