Tumor-induced endothelial RhoA activation mediates tumor cell transendothelial migration and metastasis
Md Sanaullah Sajib, Fatema Tuz Zahra, Μαργαρίτα Λάμπρου, Racheal Grace Akwii, Jee Hyun Park, Manuel Osorio, Paul Tullar, Colleen L. Doçi, Chonghe Zhang, Stephan Huveneers, Jaap D. van Buul, Minghai Wang, Maciej M. Markiewski, Sanjay Srivastava, Yi Zheng, , Constantinos Marios Mikelis
This study identifies endothelial RhoA activation as a key driver of tumor cell transendothelial migration and metastasis, showing it can be inhibited to reduce metastatic potential.
bioRxiv · Sep 22, 2024 · PreprintPhysiology