Author

Maciej M. Markiewski

Texas Tech University Health Sciences CenterORCID 0000-0002-8271-8918Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Anil Kumar KalvalaiD· 1 shared Apoorva Kasetti· 1 shared Ashok SilwaliD· 1 shared Bhaumik B. PateliD· 1 shared Bo R. RuedaiD· 1 shared Chonghe ZhangiD· 1 shared Colleen L. DoçiiD· 1 shared Constantinos Marios MikelisiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Anil Kumar KalvalaORCID

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2 papers

Recent·Most cited

Extracellular vesicles regulate metastable phenotypes of lymphangioleiomyomatosis cells via shuttling ATP synthesis to pseudopodia and activation of integrin adhesion complexes.

Anil Kumar Kalvala, Ashok Silwal, Bhaumik B. Patel, Apoorva Kasetti, Kirti Rajendra Shetty, Jan Markiewski, Jun‐Hung Cho, Gerard Lara, Elizabeth A. Daugherity, Rémi Diesler, Venkatesh Pooladanda, Bo R. Rueda, Elizabeth P. Henske, Jane J. Yu, Maciej M. Markiewski, Magdalena Karbowniczek

This study shows that extracellular vesicles from LAM cells promote metastasis by delivering ATP to pseudopodia and activating integrin adhesion complexes.

Communications Biology · Nov 20, 2025Peer-reviewedCancer Biology

Tumor-induced endothelial RhoA activation mediates tumor cell transendothelial migration and metastasis

Md Sanaullah Sajib, Fatema Tuz Zahra, Μαργαρίτα Λάμπρου, Racheal Grace Akwii, Jee Hyun Park, Manuel Osorio, Paul Tullar, Colleen L. Doçi, Chonghe Zhang, Stephan Huveneers, Jaap D. van Buul, Minghai Wang, Maciej M. Markiewski, Sanjay Srivastava, Yi Zheng, , Constantinos Marios Mikelis

This study identifies endothelial RhoA activation as a key driver of tumor cell transendothelial migration and metastasis, showing it can be inhibited to reduce metastatic potential.

bioRxiv · Sep 22, 2024 · PreprintPhysiology