Todd L. Fallesen

Stage-specific checkpoint signalling by ATM, ATR and DNA-PK safeguards oocyte genome integrity

This study investigates how ATM, ATR, and DNA-PK signaling differ in their roles during meiotic recombination and postnatal DNA damage response in mouse oocytes, revealing distinct pathways for oocyte elimination.

Distinct ATRX functions cooperate with 9-1-1 and CST complexesto safeguard replication and telomere integrity

This study identifies distinct roles of ATRX in safeguarding genome and telomere integrity through interactions with CST and 9-1-1 complexes, revealing context-dependent mechanisms.

Investigations into fission yeast chromosome size determinants

This study investigates chromosome size determinants in fission yeast and finds that condensin levels, not cell or nuclear volume or mitosis duration, primarily influence chromosome dimensions.

Progressive chromosome shape changes quantified during cell divisions

The paper quantifies progressive changes in chromosome shape during cell divisions and finds that an alternative loop capture model explains the observed arm length to width relationship better than the loop extrusion model.

KLF17 promotes human naïve pluripotency but is not required for its establishment

The paper shows KLF17 can induce a naive-like transcriptome in primed hESCs but is not required for naive pluripotency establishment in vitro.

A fuzzy-registration approach to track cell divisions in time-lapse fluorescence microscopy

This paper introduces a fuzzy-registration algorithm for tracking cell divisions in time-lapse fluorescence microscopy, validated on Arabidopsis root mitotic events.

Neuronal programming by microbiota enables environmental regulation of intestinal motility

The paper shows microbiota induce AhR in enteric neurons, enabling them to respond to environmental signals.