Author

Maria Lefaki

National Hellenic Research Foundation

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Niki ChondrogianniiD· 2 shared Aleksandar BartolomeiD· 1 shared Alessandro CellerinoiD· 1 shared Alessandro Ori‬‬iD· 1 shared Aristotelis A. ChatziioannouiD· 1 shared Cinzia CaterinoiD· 1 shared Domenico Di FraiaiD· 1 shared Dorothee ChildsiD· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersSystems Biology

Niki ChondrogianniORCID

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2 papers

Recent·Most cited

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Erika Kelmer Sacramento, Joanna M Kirkpatrick, Mariateresa Mazzetto, Mario Baumgart, Aleksandar Bartolome, Simone Di Sanzo, Cinzia Caterino, Michele Sanguanini, Nikoletta Papaevgeniou, Maria Lefaki, Dorothee Childs, Sara Bagnoli, Eva Terzibasi Tozzini, Domenico Di Fraia, Natalie Romanov, , Alessandro Ori‬‬

This study shows that reduced proteasome activity in aging brains leads to ribosome stoichiometry loss and aggregation, increasing mortality risk in killifish.

Molecular Systems Biology · Jun 1, 2020Peer-reviewedSystems Biology

Qualitative modeling of signaling networks in replicative senescence by selecting optimal node and arc sets

Theodore Sakellaropoulos, Ilona Binenbaum, Maria Lefaki, Aristotelis A. Chatziioannou, Niki Chondrogianni, Leonidas G. Alexopoulos

The paper presents a method to qualitatively model signaling networks by integrating experimental data and protein connectivity, showing that senescent cells are less responsive to insulin and activate senescence pathways.

bioRxiv · Aug 10, 2018 · PreprintSystems Biology