Sara Bagnoli

MicroRNA-29 acutely regulates Memory Stability, Expression of Synaptic Genes, and DNA Methylation in the Mouse Adult Hippocampus

This study shows that miR-29 regulates memory stability, synaptic gene expression, and DNA methylation in adult mouse hippocampus by modulating Dnmt3a levels.

Amyloid-beta precursor protein contributes to brain aging and learning decline

This study shows that amyloid-beta precursor protein contributes to non-pathological brain aging and learning decline in killifish and humans.

Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brain

The paper shows that aging in killifish brains reduces basic amino acid-rich proteins through translation pausing, not transcription or proteasome issues, revealing a vulnerability in nucleic-acid protein biogenesis.

Aging is associated with a degeneration of noradrenergic-, but not dopaminergic-neurons, in the short-lived killifish Nothobranchius furzeri.

The paper confirms age-dependent noradrenergic neuron degeneration in killifish, with early phospho-Synuclein presence, but not dopaminergic neuron loss.

New lessons on TDP-43 from the killifish N. furzeri

This paper demonstrates that TDP-43 paralogs in the killifish N. furzeri form amyloid-like aggregates during ageing, suggesting the fish as a model for TDP-43-related neurodegenerative diseases.

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

This study shows that reduced proteasome activity in aging brains leads to ribosome stoichiometry loss and aggregation, increasing mortality risk in killifish.