Pierre Gestraud

Integrated multiomic profiling reveals SWI/SNF subunit-specific pathway alterations and targetable vulnerabilities

The paper identifies pathway alterations and targetable vulnerabilities in SWI/SNF-defective cancers through multiomic profiling and drug screening.

DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation

This study shows that DNA methylation is critical for restricting neural differentiation but not germline fate in ESCs, with TKO ESCs capable of germline specification.

Intronic polyadenylation isoforms in the 5' part of genes constitute a source of microproteins and are involved in cell response to cisplatin

The paper identifies microproteins encoded by intronic polyadenylation isoforms in the 5' part of genes and shows their role in modulating cisplatin response in cancer cells.

MET functions in tumour progression and therapy resistance are repressed by intronic polyadenylation

The paper shows that intronic polyadenylation (IPA) of MET affects tumour progression and therapy resistance by producing a short MET isoform that reduces invasiveness and enhances response to MAPK-targeted therapy.

Differential screening identifies molecules specifically inhibiting CCR5 transport to the cell surface and HIV infection

The paper identifies molecules that inhibit CCR5 transport to the cell surface and HIV infection by targeting palmitoylation.