Author

Pascal St-Onge

Centre Hospitalier Universitaire Sainte-JustineORCID 0000-0002-9322-1034Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Daniel SinnettiD· 2 shared Gabrielle McInnes· 2 shared Maxime CaroniD· 2 shared Serge McGrawiD· 2 shared Alexandra Langford‐AvelariD· 1 shared Anaïs DarracqiD· 1 shared André Haman· 1 shared Annie Beaudry· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Daniel SinnettORCID

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2 papers

Recent·Most cited

Time-dependent chromatin maturation during 3D spheroid culture improves preclinical modeling of non-small cell lung cancer

Anaïs Darracq, Nicolas Sgarioto, Marielle Huot, Gabrielle McInnes, Antoine Méant, Alexandra Langford‐Avelar, Oscar David Villarreal, François Marois, Maxime Caron, Pascal St-Onge, Séverine Leclerc, Gaël Cagnone, Grégor Andelfinger, Stéphane Richard, Daniel Sinnett, , Noël J.‐M. Raynal

This study shows that 3D spheroid culture of NSCLC cells undergoes time-dependent chromatin and transcriptomic changes that improve drug response prediction and correlation with tumors.

bioRxiv · Jan 23, 2025 · PreprintCancer Biology

Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin Through Downregulation of Histone Acetyltransferases

Elodie M. Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gaël Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Chantal Richer, Pascal St-Onge, Jeffrey R. Johnson, Nevan Krogan, Yuka Sai, Michael Downey, Moutih Rafei, Meaghan Boileau, , Noël J-M Raynal

This study shows proscillaridin, a cardiac glycoside, selectively targets MYC overexpressing leukemia by downregulating histone acetyltransferases and inducing hematopoietic differentiation.

bioRxiv · Dec 11, 2018 · PreprintPharmacology & Toxicology