Author

Leigh Goedeke

Icahn School of Medicine at Mount SinaiORCID 0000-0002-7690-1572Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1

Frequent Co-Authors

Aidan Warnock· 2 shared Chung Hwan ChoiD· 2 shared Kajal Davi· 2 shared Niki F. BrisnovaliiD· 2 shared Prashant RajbhandariiD· 2 shared Ramazan Yildiz· 2 shared YoungUk JangiD· 2 shared Daniel J. PulestoniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

Aidan Warnock

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Regulatory T cells establish an IL-10-IL10R immunometabolic checkpoint that limits HSL activation and lipolysis

Ramazan Yildiz, Kajal Davi, Niki F. Brisnovali, James W.R. McMullen, Chung Hwan Cho, Khatanzul Ganbold, YoungUk Jang, Njeri Z. R. Sparman, Aidan Warnock, Gabriel Deards, Leigh Goedeke, Prashant Rajbhandari

This study identifies Tregs as an immunometabolic checkpoint that limits HSL activation and lipolysis via IL-10-IL10R signaling in adipose tissue.

bioRxiv · Jul 13, 2026 · PreprintCell Biology

Tetherin enforces an immunometabolic checkpoint that coordinates glycolytic and interferon signaling in adipocytes

Chung Hwan Cho, YoungUk Jang, Aidan Warnock, Ramazan Yildiz, Jing Jhang, Kajal Davi, Niki F. Brisnovali, Victoria Huhn, Peng Wang, Romina Bevaqua, Leigh Goedeke, Michael Schotsaert, Mirela Berisa, Daniel J. Puleston, Prashant Rajbhandari

This study identifies Tetherin as an immunometabolic checkpoint in adipocytes that restricts type I interferon signaling while preserving glycolytic capacity, improving metabolic homeostasis.

bioRxiv · Jul 7, 2026 · PreprintCell Biology

Role of AMPK in Atrial Metabolic Homeostasis and Substrate Preference

Zeren Toksoy, Yina Ma, Leigh Goedeke, Wenxue Li, Xiaoyue Hu, Xiaohong Wu, Marine Cacheux, Yansheng Liu, Fadi G. Akar, Gerald I. Shulman, Lawrence H. Young

This study shows that atrial AMPK deletion shifts metabolism from fatty acid oxidation to pyruvate oxidation and disrupts metabolic pathways, contributing to atrial remodeling and arrhythmia.

bioRxiv · Aug 29, 2024 · PreprintPhysiology