Adolescent prodromal phenotypes of psychiatric disorders: insights from a novel DISC1-perturbed monkey model
Ziguo Lan, Hirotaka Onoe, Tomoyuki Tsukiyama, Chizuru Iwatani, Chih-Yang Chen, Keisuke Okita, Koko Ishizuka, Ryo Endo, Risako Nakai, Keiko Imamura, Keigo Hikishima, Hideaki Tsuchiya, Masataka Nakaya, Yang Fang, Atsushi Kobayashi, , Tadashi Isa
This paper presents a novel monkey model with impaired DISC1 gene to study adolescent prodromal phenotypes of psychiatric disorders, finding altered social behavior and disrupted brain connectivity.
bioRxiv · Oct 18, 2026 · PreprintNeuroscience