CRISPR-mediated biocontainment
Oscar Castanon, Cory J. Smith, Parastoo Khoshakhlagh, Raphaël Ferreira, Marc Güell, Khaled Said, Ramazan Yildiz, Matthew Dysart, Stan Wang, David B. Thompson, Hannu Myllykallio, George McDonald Church
The paper develops CRISPR-based biocontainment circuits using transposable elements to induce cell death and create kill-switches for controlling cell lines.
bioRxiv · Feb 3, 2020 · PreprintSynthetic Biology