Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypes
Ghazal Sadri, Steven T. Nadakal, William Lauer, Justin T. Kos, Parmit Kumar Singh, Erin Elliott, Catherine W. Kaiser, Easton E. Ford, Nadia Richardson, Kaitlyn M. Shields, Elizabeth Hudson, Noemi Linden, Ali Danesh, James Powell, Peter E. Warburton, , Melissa Laird Smith
The paper introduces HIV SMRTcap, a method for characterizing HIV-1 reservoirs by identifying integration sites and proviral integrity using long-read sequencing, and validates its performance across subtypes and tissue samples.
PLoS Pathogens · Jan 13, 2026Peer-reviewedGenomics