Author

Matthew Gigliotti

Rutgers, The State University of New Jersey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

David DegeniD· 2 shared Kalyan DasiD· 2 shared Richard H. EbrightiD· 2 shared Sukhendu MandaliD· 2 shared Wei LiniD· 2 shared Yi Jiang· 2 shared Yon W. EbrightiD· 2 shared Aashish SrivastavaiD· 1 shared

Activity by Year

2017-2018 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

David DegenORCID

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2 papers

Recent·Most cited

Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3)

Wei Lin, Kalyan Das, David Degen, Abhishek Mazumder, Diego Duchi, Dongye Wang, Yon W. Ebright, Richard H. Ebright, Elena V. Sineva, Matthew Gigliotti, Aashish Srivastava, Sukhendu Mandal, Yi Jiang, Yu Liu, Ruiheng Yin, , Achillefs N. Kapanidis

This paper reports the cryo-EM structure of Mycobacterium tuberculosis RNAP holoenzyme bound to fidaxomicin, revealing its unique binding site and mechanism of transcription inhibition.

Molecular Cell · Mar 29, 2018Peer-reviewedMolecular Biology

Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition

Wei Lin, Soma Mandal, David Degen, Yu Liu, Yon W. Ebright, Shengjian Li, Yu Feng, Yu Zhang, Sukhendu Mandal, Yi Jiang, Shuang Liu, Matthew Gigliotti, Meliza T. Talaue, Nancy D Connell, Kalyan Das, , Richard H. Ebright

This study reports crystal structures of Mycobacterium tuberculosis RNA polymerase with and without antituberculosis drugs, revealing a new class of inhibitors and their binding mechanisms.

Molecular Cell · Apr 1, 2017Peer-reviewedMolecular Biology