Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity
Abdelhakim Boudrioua, Joe D. Joiner, Iwan Grin, Thales Kronenberger, Vadim S. Korotkov, Wieland Steinchen, Alexander Kohler, Sophie Schminke, Julia-Christina Schulte, Michael Pietsch, Arun Naini, Simon Kalverkamp, Sven‐Kevin Hotop, Travis Coyle, Claudio Piselli, , Samuel Wagner
The paper identifies a synthetic small molecule, C26, that inhibits HilD, a key regulator of Salmonella secretion systems, thereby preventing bacterial invasion of host cells.
Science Advances · Apr 11, 2025Peer-reviewedMicrobiology