Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C-terminal Hydrolase L3
Nagabhushana C. Beeralingappa, Mengyao Lu, Rishi S. Patel, Nipuni M. Pannala, Alisha Dhiman, Brittany N. Heil, Ryan D. Imhoff, Emily G. Smith, Mei B Bahler, Haley L Marsden, Brittany L. Allen-Petersen, Mike Wendt, Chittaranjan Das, Daniel Patrick Flaherty
This study identifies and optimizes a chloroacetamide scaffold as a covalent inhibitor for UCHL3, supported by structural and biochemical validation.
bioRxiv · May 29, 2026 · PreprintPharmacology & Toxicology