Federico Corona

This study shows that single-site DNA methylation activates Retron-Sen2 by enabling RcaT tetramerisation, leading to retron disassembly and toxicity.

This study reveals that phage T7 kinase broadly phosphorylates host and phage proteins, disabling bacterial defense systems through widespread phosphorylation.

The paper develops EVADES, a database of phage anti-defence proteins, predicts mechanisms for 21 uncharacterized ADPs, and explores their evolutionary and functional relationships.

This study identifies nitroxoline's broad antibacterial activity against Gram-negative bacteria, its mode of action involving metal homeostasis and outer membrane disruption, and resistance mechanisms across multiple species.