Specific F1 ATP synthase inhibition delivers transient mitochondrial stress for selective targeting of acute myeloid leukemia
Matthew T. Villaume, Haley Elizabeth Ramsey, Valeria Impedovo, Michael Davidson, Maria Pia Arrate, Anand Kamal Singh, Yujin Lee, Anna Skwarska, Yara. F. Almadani, Natalia Baran, Sovira Chaudhry, Benjamin J. Reisman, Eden G. TenBarge, Ming Jiang, Sarah D. Olmstead, , Michael Robert Savona
This study shows that inhibiting F1 ATP synthase with EB2023 causes transient mitochondrial stress in AML cells, enabling effective treatment without harming healthy tissues.
bioRxiv · Jul 13, 2026 · PreprintCancer Biology