Macronutrient Composition and Genetic Background Determine the Response to a Ketogenic Diet
Zhaoyue Zhang, Alexandre Moura‐Assis, S Liu, Alon Millet, Jordan Shaked, Divya Rajan, Hanan Alwaseem, Michael Isay-Del Viscio, Henrik Molina, Kıvanç Birsoy, Jeffrey M. Friedman
This study shows that macronutrient composition and genetic background influence the response to a ketogenic diet in mice, with B6J mice losing weight on a low-protein KD due to increased GDF15 and LCN2 levels.
bioRxiv · Apr 27, 2026 · PreprintPhysiology