Romain Donné

Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoidstructures in cancer

This study identifies the role of mature dendritic cells type 1 in forming, maintaining, and functioning tertiary lymphoid structures in cancer.

Bacteroidetes promote hepatocellular carcinoma progression and resistance to immunotherapy

This study identifies Bacteroidetes enrichment as a biomarker of immunotherapy resistance in hepatocellular carcinoma and shows its pro-tumorigenic effects in mouse models.

Tumor Genotype Dictates Mitochondrial and Immune Vulnerabilities in Liver Cancer

This study identifies genotype-specific mitochondrial metabolic vulnerabilities in liver cancer and shows that phosphatidylethanolamine synthesis contributes to immune evasion.

TREM2 macrophages are associated with enhanced response to PD-1 blockade in human hepatocellular carcinoma

The paper identifies TREM2-expressing macrophages as predictors of response to PD-1 blockade in HCC patients using clinical and spatial transcriptomic data.

NOTCH1 drives tumor plasticity and metastasis in hepatocellular carcinoma

This paper develops a novel mouse model showing NOTCH1 drives temporal plasticity and metastasis in hepatocellular carcinoma through angiogenesis and TGFβ pathways.