Author

Manuel Etzkorn

Heinrich Heine University DüsseldorfORCID 0000-0002-9796-3246Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Andreas TrumppiD· 1 shared Andresa MessiasiD· 1 shared Antonio Martı́nez-RuiziD· 1 shared Ashok Kumar JayaveluiD· 1 shared Biplab GhoshiD· 1 shared Carsten BerndtiD· 1 shared Daniel Pastor‐FloresiD· 1 shared Dario Ariel EstriniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Andreas TrumppORCID

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2 papers

Recent·Most cited

Sodium Aurothiomalate Induces Ferroptosis by Targeting GPX4 via Gold-Dependent Thiomalate Covalent Modification

Martín Hugo, Lissy Z. F. Gross, Andresa Messias, Lucía Alcober-Boquet, Thibaut Vignane, Biplab Ghosh, Nesrine Aroua, Lora Denson, Susana Delgado‐Martín, Kamini Kaushal, Umut Yildiz, Sebastian Müller, Antonio Martı́nez-Ruiz, Dario Ariel Estrin, Hellmut G. Augustin, , Hamed Alborzinia

This study shows sodium aurothiomalate induces ferroptosis by covalently modifying GPX4 through a gold-dependent mechanism, leading to tumor growth reduction in preclinical models.

bioRxiv · Nov 13, 2025 · PreprintBiochemistry

Identification of non-charged 7.44 analogs interacting with the NHR2 domain of RUNX1-ETO and exhibiting an improved, selective antiproliferative effect in RUNX-ETO positive cells

Mohanraj Gopalswamy, David Bickel, Niklas Dienstbier, Jia‐Wey Tu, Melina Vogt, Stephan Schott‐Verdugo, Sanil Bhatia, Manuel Etzkorn, Holger Gohlke

The paper identifies non-charged analogs of the inhibitor 7.44 that show improved antiproliferative effects against RUNX1-ETO positive cells.

Scientific Reports · May 21, 2025Peer-reviewedPharmacology & Toxicology